6/5/20233 min read



With the growing demand for non-surgical facial rejuvenation procedures, more and more people are turning to neuromodulators like Botox and Xeomin to smooth out wrinkles and lines on the face. While both products are widely recognized for their effectiveness, there are some key differences between them that may influence which product individuals choose for their treatment needs. In this article, we will explore 20 differences between Xeomin and Botox in more detail to help individuals make an informed decision about which product may be right for them.


1. Composition:

Xeomin and Botox differ in their composition. Xeomin contains only Botulinum toxin, while Botox contains Botulinum toxin along with certain proteins.

2. Manufacturing:

Xeomin is manufactured using a special process that removes all the impurities and proteins from the Botulinum toxin, while Botox is manufactured using a conventional process that retains the proteins.

3. Purity:

Due to its special manufacturing process, Xeomin is considered purer than Botox.

4. Allergies:

The presence of proteins in Botox can cause allergic reactions in some people, while Xeomin is considered a safer option for patients who are allergic to the proteins found in Botox.

5. Dosage:

The dosages of Xeomin and Botox differ from each other. During each session, Xeomin may require more units than Botox to achieve the same results.

6. Effect time:

Xeomin may start showing results quicker than Botox, sometimes within a few days after treatment.

7. Effect duration:

Botox is generally considered to have a longer duration of effect than Xeomin, often up to six months or longer.

8. Injection technique:

Although the injection technique for both Xeomin and Botox is similar, some practitioners may prefer injecting Xeomin in a different way or location than Botox.

9. Type of wrinkles or lines:

The choice of using Xeomin or Botox may depend on the type of wrinkles or lines being targeted. Xeomin may be more effective in treating dynamic wrinkles, like crow’s feet, while Botox may be more effective in treating static wrinkles, like forehead furrows.

10. Labeling:

Xeomin has unique labeling and dosing information that differentiates it from Botox.

11. Dilution:

Xeomin and Botox require different dilution techniques based on the volume of saline added.

12. Storage:

Both products need to be stored at different temperatures and conditions post-reconstitution.

13. Price:

In general, Xeomin may be less expensive than Botox because it requires a higher dosage for treatment.

14. Results for Men:

Xeomin may be milder on men’s faces than Botox.

15. Activation time:

Once Xeomin is injected, it is activated directly, while Botox takes some time to bind with nerve receptors.

16. Shelf Life:

Xeomin has a longer shelf life than Botox when stored before use.

17. Spread:

Due to the absence of certain proteins, Xeomin may have less spread than Botox.

18. Treatment regularity:

Xeomin may require more frequent treatments than Botox.

19. Company:

Xeomin is manufactured by Merz Pharmaceuticals, while Botox is made by Allergan.

20. FDA Approval:

Both Xeomin and Botox are FDA approved for cosmetic treatments, but Botox is FDA approved for additional medical indications like migraines and muscle spasms.


Ultimately, the choice between Xeomin and Botox will depend on the individual patient's needs and preferences, as well as their medical history and any potential allergies. It's important to talk to a qualified healthcare provider about the best treatment options for your specific needs.

Xeomin and Botox are both popular neuromodulators used to treat wrinkles and lines on the face. However, they differ in their composition, manufacturing, dosage, effectiveness, and price. While Xeomin may be considered safer for those with allergies, it may require more frequent treatment and have a higher number of units per session than Botox. In contrast, Botox may have a longer duration of effect and be more effective in treating static wrinkles. It is important to consult a qualified medical professional to determine which product is best suited for individual treatment needs.